HomeArticles23andMe EXPLAINED | Gujarati Boy DNA Genetic Test Results
23andMe EXPLAINED | Gujarati Boy DNA Genetic Test Results
December 3, 2019
Bulls**t I can’t smell asparagus! What’s up guys
in this episode, I go through 23andMe and how reliable the results might be for a
South Asian or Indian or Pakistani Bangladeshi or Sri Lankan. So keep
watching if you want to find out. Time to get our hands dirty.
On a side note, don’t you think it’s really odd that after google searching
23andMe Facebook now thinks I might be interested in buying it? Anyway how
reliable are your results from 23andMe? Should you trust absolutely everything
that 23andMe says? Or should you take it with a grain of salt? Or should it be
something in between? We’re gonna find out. I thought of making this video after
I watched this one, and I realized that a lot of genetically identical twins are
getting separate results. So 23andMe thinks that their genetic heritage are
different. Is this even possible? No! It’s quite easy to be misinformed about what
23andMe actually does to your DNA samples. So most people have 23 x 2
or 46 chromosomes. In those chromosomes there are about 3 billion base pairs.
23andMe is not sequencing all 3 billion of those base pairs. That would be way
too expensive for a service that’s around a hundred dollars or a hundred
pounds. 23andMe looks at what are called SNPs “snips”. SNPs are essentially tiny
variations in your genome that can express certain outcomes. There are
certain SNPs or variations in genomes that can result in certain types of
diseases. There are certain SNPs that only people of certain geographical
locations might have. They might have not been born in that area but the people
that were originally located in that region would have had those SNPs.
Detecting those snips in your genome, 23andMe can tell whether you’re Polish
or German or Indian or West Indian. 23andMe is essentially making
conclusions from the tiny variations in your genome, and
looks at those genotypes and thinks that those genes are going to express certain
types of proteins that result in this type of expression. And this type of
expression in terms of proteins will result in a person with a certain
characteristic. It’s very important that I mention here that a lot of factors
actually contribute towards the way a person might be or the way you are, the
things you like and the diseases that you might contract in your lifetime. It’s
not just genotype. Which means that if you smoke (a lot) it’s very likely that at some
point in your life you may end up getting lung cancer. Genes are not
everything, environment also plays a very, very strong role in getting diseases
like cancers. Ao let’s have a look at my ancestry report. Okay that was a complete waste of money.
If your second name is Patel, let me do you a favor and tell you where you’re
from. It’s really important to remember that the results you’re getting from
your 23andMe analysis only represents what is a probability of you getting a
certain outcome. If your 23andMe results are saying that you have a high
likelihood of late onset Alzheimer’s disease, it doesn’t mean that you’re
necessarily gonna get Alzheimer’s disease. It just means that probabilistic
algorithms are pointing towards a higher risk of late onset Alzheimer’s in you.
I love how an article in the Scientific American has put this. They say that
genetics is a probabilistic science and there is no gene that codes for anything
in particular. It’s genes, together plus environment that lead to consequences.
Even having genes like those for blue eyes does not necessarily always
correspond to having blue eyes. It’s still a probability. So although it was
quite a lot of fun to find out that I am 100% Indian, which I always knew, I would
say there was actually no use at all from it. It may be exciting to read genetic
analysis reports for the first time but at the end of the day, 23andMe is relying
on entertaining you rather than actually giving you something for certain or for
sure. My verdict is that do not take 23andMe or other genetic tests (especially those relying on SNPs) seriously
at this point in time. There are definitely going to be be ways to get genetic
analyses done for cheaper prices and with higher accuracy in the future. The
price of a report right now is about $200. Granted 23andMe is an excellent
service for many people and is pioneering a whole new area of research.
But on the other hand it got quite a few things wrong. I don’t hate cilantro or
coriander as it predicted. I actually love coriander. I’m Indian, come on!
And I don’t personally believe my caffeine consumption is lower than
average. If there’s anything else that you would like me to review then let me
know in the comments section below. Thanks for watching guys. Have a nice day!