DNA Origami: folding on the smallest scale


Thank you. Thank you. 2
00:01:05 150 –>00:01:05 479 That’s amazing. 3
00:01:05 479 –>00:01:09 300 Thank you. Hey, why don’t you take a seat? Thanks. That is really fascinating. Yes, it is wonderful how you can make something
so complex out of something really simple. really simple. Yes, the possibilities are
endless and the material is just everywhere. Definitely. Hey, do you
fold as well? Actually I do fold. I fold DNA. DNA? I didn’t know that was possible! Let me show you how. DNA origami follows one simple rule. Whenever two strands of DNA match they
bind and form a double helix. What if you want to make a crocodile? You use DNA that binds in different places. And DNA origami is so simple. You draw to shape you want on the
computer the computer calculates the 17
00:02:21 969 –>00:02:23 359 sequences you need you email the sequences off to a company
and then you get such a little white box.
Each of the wells here contains one DNA sequence. That sounds like something from science
fiction. But since 2006 it’s been a 22
00:02:42 150 –>00:02:42 950 reality So, shall we make some origami then? Yes,
let’s. Then we just need to mix. I am now just pipetting DNA in water. so each of the droplets now contains
one DNA sequence. We mix them with a pipette tip and put them in this tube and then we need to heat and the DNA
origami is ready If your paper origami model was the size of the actual DNA origami channel
then a grain of sand would be the size of Mount Everest. Really? So you are a nano
designer? Maybe. But just like origami has
applications in the real world like 33
00:03:48 740 –>00:03:51 200 folding airbags to make cars safer we’re also working towards applications.
We’re trying to make these small 35
00:03:55 640 –>00:04:00 20 channels from DNA origami. We can make them change size and shape
reacting to their environment. We can make them punch holes into
membranes and we can even make them glow by attaching special molecules to DNA. How do you know the DNA channels actually
punch holes into membranes when they are too small to see? Good point.
It’s very hard to observe a single channel 41
00:04:24 310 –>00:04:25 360 directly but we can observe their function. We
seal this glass capillary with a membrane.
When a channel punches a hole into this membrane the
seal is no longer perfect and we can observe a current going through. Okay. That’s pretty cool. But is it as cool as origami crocodiles? Many genetic diseases lead to defective
channels in cells. Now imagine what we could do if we could
create artificial channels for every patient
that way we need them. With DNA origami we can build on
the nanoscale. A versatile tool with versatile
applications from medicine to 53
00:05:12 880 –>00:05:14 530 miniaturized computers. We may be curious to see what is yet to
come.

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