DNA Replication Animation – initiation, elongation and termination


Process of bacterial DNA replication involves
a number of proteins coming together in a complex machine DNA replication begins at
a single defined DNA sequence of 245 base pairs called only see a protein called DNA
increases in concentration as a cell grows and gets very cell division this protein as
a complex with ATP can force the onset of initiation by binding to specific nine base
pairs repeat or EC the binding distorts the DNA leading to the opening of the adjacent
13 base pairs repeats in the DNA of the opening of the DNA allows protein complexes to enter
the replication bubble and bind to the single-stranded DNA each complex consist of the DNA humour
case also called DNA B and a DNA fever caseload are also called DNA see the DNA fever caseload
is open the DNA humour case protein rings in place the wings around the single-stranded
DNA promoters are then released the humour cases use energy from ATP hydrolysis to unwind
the DNA helix a tribute to replication forks its DNA humour case recruit an enzyme called
DNA primates which synthesisers and RNA primer, DNA template and RNA primer is on its and
a three prime hydroxyl group which is required as a starting point for DNA polymerase to
add DNA nucleotides the replication polymerase in E. coli is called DNA polymerase three
DNA polymerase three complexes of the rate of application forts by protein complexes
called clear borders) is also clearly of the protein complexes called sliding clamps the
clear blue replaces the sliding clamp onto the DNA and places and attached DNA polymerase
three complex next to the sliding clamp the sliding clamp holds the DNA polymerase imposition
on the three prime to the growing spray and as the polymerase synthesises new DNA nucleotides
with complimentary basis to the tablet or one by one in the five prime to 3 prime direction
the synthesis of DNA in the direction of the fourth occurs continuously to the end of the
tablet piecemeal squared is called the leading sway and in contrast the other blue sky and
call the lagging strand is built in fragments called Okazaki fragments a simplified diagram
shows the key differences in the leading and lagging span is known to the tablet scram
is a type well with a three prime and five prime a.m. is all you need in opposite directions
because DNA polymerase can add nucleotides only in the five prime to 3 prime direction
leading strand grows continuously in the direction of the replication fork providing spray and
can grow only in short segments as the parental DNA molecule unzips many proteins participate
in DNA replication including those called single-stranded DNA binding proteins which
quickly code exposed single-stranded regions of DNA and protect the single-stranded DNA
from attack by nuclease is all those single-stranded DNA binding proteins are present throughout
replication for simplicity we will make the in the rest of the process DNA replication
continues as the DNA polymerase providing spray and meets the five prime end of the
next primer causing the polymerase of the sliding clamp to disengage of the DNA humour
case has moved approximately 1000 pieces as second RNA primer is synthesised of the fork
the sliding clamp loader adds a new sliding clamp to the primer and then add the DNA polymerase
to begin synthesis on a new Okazaki fragment the cycle continues for the wake of the template
strands of the lagging strand now consist of Okazaki fragments with the segment of RNA
at one and the RNA is cleaved by an enzyme called RNase H
another enzyme called DNA polymerase one uses
the three prime of age group of the adjacent Okazaki fragment to fill a large gap with
the DNA nucleotides finally an enzyme called DNA ligase closes the remaining makes on the
DNA leading a continuous DNA molecule in this way in E. coli chromosome is replicated at
to replication forks all the way around the circular molecule

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