MapS Phasing | Adding Relatives


Hello everyone, and thank you for your interest in MapS Phasing. In this video, I will show you how to add relatives to your phasing project in MapS Phasing. Adding relatives to your phasing project can greatly improve the quality of the phasing results. If you only have a child and a parent, there will be a number of SNPs that the phasing algorithm cannot resolve because both, the child and the parent, are heterozygous at that position. Bringing in raw data from other relatives can help solve this problem. To add relatives to your project, you will again have to extract the raw data files from the *.zip-archives first. As you can see here, I have already extracted 3 files that belong to paternal and maternal cousins. After you have extracted the raw data files, open MapS Phasing and add the information of the family group. I have already done this for our example. Now, we can add a relative by clicking on the icon on the right and choosing “relative”. In the window that appears you can choose the raw data file for the relatives. You can also add a name for the relative, but you don’t have to. Adding a name, however, can be helpful to understand how the relatives were used in the phasing process later. Once you have loaded the files, you can already start the phasing algorithm. However, I would like to show you the settings that you can adjust and thereby finetune the phasing results first. Click on the wrench in the upper left corner, and you will find a bunch of settings. Each setting has a short explanation to the right. You don’t have to modify any of these settings – the predefined values should work for most cases. However, if the results are not what you expect, you might want to try to adjust some of the standard values. You can always come back to the predefined settings by clicking “restore defaults”. Now, all that’s left to do is click start and wait. Adding relatives will increase the run time of the phasing algorithm. This was a short explanation of how to add relatives to your phasing project. My name is Hendrik Wendland and if you have any questions, concerns or suggestions, please feel free to email me at [email protected] Again, thank you for your interest in MapS Phasing and I wish you all the best for your genealogical endeavors.

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